MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a peptide encoded by mitochondrial DNA. It plays an important
role in regulating metabolism, insulin sensitivity, and cellular stress responses. Research suggests MOTS-c may promote metabolic
flexibility, improve exercise capacity, and support healthy aging.
Key Benefits
• Metabolic Regulation: Enhances insulin sensitivity and glucose metabolism.
• Exercise Performance: Improves endurance and energy utilization.
• Healthy Aging: Supports mitochondrial function and cellular resilience.
• Weight Management: May help regulate fat metabolism.
Clinical Findings
• Preclinical studies show improved glucose tolerance and reduced obesity-related metabolic dysfunction.
• Animal research indicates enhanced physical performance and protection against diet-induced obesity.
• Early human studies suggest MOTS-c influences exercise response and energy regulation.
Safety & Tolerability
• Limited safety data — primarily from animal and early-stage human studies.
• No major adverse effects reported to date.
• Long-term human safety remains under investigation.
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